Research in this project is funded by   http://www.agence-nationale-recherche.fr/Accueil   and   http://www.bbsrc.ac.uk/

Difference between revisions of "PheroSys:About"

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== Scientific Abstract ==
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PheroSys is a joint project of three research groups financed in the framework of the joint SysBio intiative of the ANR (http://www.agence-nationale-recherche.fr/ ) and the BBSRC (http://www.bbsrc.ac.uk/index.html).
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The aim of our project is to investigate olfactory information processing in the first stages of the olfactory pathway. We will conduct experiments and modelling studies in the pheromone subsystem of the moth Spodoptera littoralis (the cotton leafworm).
 
  
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1. In experiments we will
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== Partners ==
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* investigate the transduction mechanism in the olfactory receptor neurons (ORNs) with tip-recording in vivo and patch clamp recordings in vitro,
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Partner 1:
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* determine the prevalence and distribution of different types of ORNs and their projections to the macro-glomerular complex (MGC), and
 
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* record the activity of MGC neurons in response to a rich set of odour stimuli while monitoring the local field potential.
 
  
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2. In modelling we will
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Coordinator of the project and French project leader: Dr Jean-Pierre Rospars
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* build detailed, biophysical models of the ORNs, combining experimental data (1b) with existing submodels of perireception, reception, and post-reception processes,
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* reconstruct the compound signal sent by the ORNs to the MGC based on modelling (2a) and experimental data (1b),
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Unité Mixte de Recherche 1272, Physiologie de l’Insecte: Information et communication, UPMC (Université Pierre et Marie Curie, Paris 6) – INRA (Institut National de la Recherche Agronomique) – AgroParisTech. INRA, Route de Saint Cyr, 78026 Versailles Cedex, France, Tel: +33 1 30 83 33 55, Fax: +33 1 30 83 31 19
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* develop conductance-based models of single glomeruli using modern data fitting technology (synchronization based parameter estimation employing genetic algorithms and multiple shooting) to adjust the models to the data (1b, 1c),
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Email: rospars@versailles.inra.fr, Web page: http://www-physiologie-insecte.versailles.inra.fr/pageJPR.php
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* reduce the detailed models to network models of IF neurons and analyse their response and coding properties mathematically, and
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* build similar detailed and reduced models of the full MGC to analyse the following open questions (in both the oneglomerulus and full MGC models):
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Coinvestigators: Dr Sylvia Anton, Dr Philippe Lucas
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** Is the connectivity of olfactory systems well described by a random network or does it follow a different construction principle?
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** How does the pheromone system achieve its outstanding sensitivity and specificity and maintain them in the presence of noise?
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Other personnel: Louise Couton (DPhil stud.), David Jarriault (DPhil stud.) and PostDocs to be named.
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** What is the origin and role of oscillations in the MGC or olfactory systems in general? What is the function of phase locking and synchronization and how does inhibition contribute to it?
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Partner 2:
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Group leader: Dr Dominique Martinez
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CORTEX Team – LORIA (Laboratoire Lorrain de Recherche en Informatique et ses Applications), Campus Scientifique BP239 - 54506 Vandoeuvre-les-Nancy, France, Tel: +33 3 83 59 30 72, Fax: +33 3 83 27 83 19
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Email : Dominique.Martinez@loria.fr, Web page: http://www.loria.fr/~dmartine
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Coinvestigators: Dr Thomas Voegtlin
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Other personnel: PostDoc and Engineer to be named.
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Partner 3:
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UK project leader: Dr Thomas Nowotny
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Centre for Computational Neuroscience and Robotics, University of Sussex, Falmer, Brighton BN1 9QJ, UK
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Tel: +44 1273 678593, Fax : +44 1273 877 873
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Email: T.Nowotny@sussex.ac.uk, Web page: http://www.sussex.ac.uk/informatics/profile206151.html
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Coinvestigators: 2 research fellows (PostDocs) to be named.
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Also see [[ Scientific Abstract ]], [[Project Summary]] and [[People]].
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== Main Objectives ==
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See the '''[[Project Summary]]''' and the '''[[Scientific Abstract]]'''.

Latest revision as of 13:43, 8 February 2010

PheroSys is a joint project of three research groups financed in the framework of the joint SysBio intiative of the ANR (http://www.agence-nationale-recherche.fr/ ) and the BBSRC (http://www.bbsrc.ac.uk/index.html).

Partners

Partner 1:

Coordinator of the project and French project leader: Dr Jean-Pierre Rospars

Unité Mixte de Recherche 1272, Physiologie de l’Insecte: Information et communication, UPMC (Université Pierre et Marie Curie, Paris 6) – INRA (Institut National de la Recherche Agronomique) – AgroParisTech. INRA, Route de Saint Cyr, 78026 Versailles Cedex, France, Tel: +33 1 30 83 33 55, Fax: +33 1 30 83 31 19 Email: rospars@versailles.inra.fr, Web page: http://www-physiologie-insecte.versailles.inra.fr/pageJPR.php

Coinvestigators: Dr Sylvia Anton, Dr Philippe Lucas

Other personnel: Louise Couton (DPhil stud.), David Jarriault (DPhil stud.) and PostDocs to be named.

Partner 2:

Group leader: Dr Dominique Martinez

CORTEX Team – LORIA (Laboratoire Lorrain de Recherche en Informatique et ses Applications), Campus Scientifique BP239 - 54506 Vandoeuvre-les-Nancy, France, Tel: +33 3 83 59 30 72, Fax: +33 3 83 27 83 19 Email : Dominique.Martinez@loria.fr, Web page: http://www.loria.fr/~dmartine

Coinvestigators: Dr Thomas Voegtlin

Other personnel: PostDoc and Engineer to be named.

Partner 3:

UK project leader: Dr Thomas Nowotny

Centre for Computational Neuroscience and Robotics, University of Sussex, Falmer, Brighton BN1 9QJ, UK Tel: +44 1273 678593, Fax : +44 1273 877 873 Email: T.Nowotny@sussex.ac.uk, Web page: http://www.sussex.ac.uk/informatics/profile206151.html

Coinvestigators: 2 research fellows (PostDocs) to be named.

Also see Scientific Abstract , Project Summary and People.

Main Objectives

See the Project Summary and the Scientific Abstract.

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