PheroSys:About - Revision history

Tnowotny: /* Main Objectives */

2010-02-08T12:43:29Z

‎Main Objectives

Tnowotny: /* Scientific Abstract */

2008-10-27T13:33:43Z

‎Scientific Abstract

Tnowotny: /* Partners */

2008-03-16T23:48:17Z

‎Partners

Tnowotny at 23:46, 16 March 2008

2008-03-16T23:46:42Z

Tnowotny: /* Scientific Abstract */

2008-03-16T23:27:14Z

‎Scientific Abstract

Tnowotny: New page: == Scientific Abstract == The aim of our project is to investigate olfactory information processing in the first stages of the olfactory pathway. We will conduct experiments and modelling ...

2008-03-16T23:20:37Z

New page: == Scientific Abstract == The aim of our project is to investigate olfactory information processing in the first stages of the olfactory pathway. We will conduct experiments and modelling ...

New page

== Scientific Abstract ==
The aim of our project is to investigate olfactory information processing in the first stages of the olfactory pathway. We will conduct experiments and modelling studies in the pheromone subsystem of the moth Spodoptera littoralis (the cotton leafworm).

1. In experiments we will
* investigate the transduction mechanism in the olfactory receptor neurons (ORNs) with tip-recording in vivo and patch clamp recordings in vitro,
* determine the prevalence and distribution of different types of ORNs and their projections to the macro-glomerular complex (MGC), and
* record the activity of MGC neurons in response to a rich set of odour stimuli while monitoring the local field potential.

2. In modelling we will
* build detailed, biophysical models of the ORNs, combining experimental data (1b) with existing submodels of perireception, reception, and post-reception processes,
* reconstruct the compound signal sent by the ORNs to the MGC based on modelling (2a) and experimental data (1b),
* develop conductance-based models of single glomeruli using modern data fitting technology (synchronization based parameter estimation employing genetic algorithms and multiple shooting) to adjust the models to the data (1b, 1c),
* reduce the detailed models to network models of IF neurons and analyse their response and coding properties mathematically, and
* build similar detailed and reduced models of the full MGC to analyse the following open questions (in both the oneglomerulus and full MGC models):
- Is the connectivity of olfactory systems well described by a random network or does it follow a different construction principle?

- How does the pheromone system achieve its outstanding sensitivity and specificity and maintain them in the presence of noise?

- What is the origin and role of oscillations in the MGC or olfactory systems in general? What is the function of phase locking and synchronization and how does inhibition contribute to it?

← Older revision		Revision as of 12:43, 8 February 2010
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	== Main Objectives ==		== Main Objectives ==
		+
		+	See the '''[[Project Summary]]''' and the '''[[Scientific Abstract]]'''.

@@ Line 34: / Line 34: @@
 Coinvestigators: 2 research fellows (PostDocs) to be named.
-== Scientific Abstract ==
+Also see [[ Scientific Abstract ]], [[Project Summary]] and [[People]].
 == Main Objectives ==

@@ Line 2: / Line 2: @@
 == Partners ==
-Partner 1: Coordinator of the project and French project leader: Dr Jean-Pierre Rospars
+Partner 1:
 Unité Mixte de Recherche 1272, Physiologie de l’Insecte: Information et communication, UPMC (Université Pierre et Marie Curie, Paris 6) – INRA (Institut National de la Recherche Agronomique) – AgroParisTech. INRA, Route de Saint Cyr, 78026 Versailles Cedex, France, Tel: +33 1 30 83 33 55, Fax: +33 1 30 83 31 19
 Email: rospars@versailles.inra.fr, Web page: http://www-physiologie-insecte.versailles.inra.fr/pageJPR.php
 Coinvestigators: Dr Sylvia Anton, Dr Philippe Lucas
 Other personnel: Louise Couton (DPhil stud.), David Jarriault (DPhil stud.) and PostDocs to be named.
-Partner 2: Group leader: Dr Dominique Martinez
+Partner 2:
 CORTEX Team – LORIA (Laboratoire Lorrain de Recherche en Informatique et ses Applications), Campus Scientifique BP239 - 54506 Vandoeuvre-les-Nancy, France, Tel: +33 3 83 59 30 72, Fax: +33 3 83 27 83 19
 Email : Dominique.Martinez@loria.fr, Web page: http://www.loria.fr/~dmartine
 Coinvestigators: Dr Thomas Voegtlin
 Other personnel: PostDoc and Engineer to be named.
-Partner 3: UK project leader: Dr Thomas Nowotny
+Partner 3:
 Centre for Computational Neuroscience and Robotics, University of Sussex, Falmer, Brighton BN1 9QJ, UK
 Tel: +44 1273 678593, Fax : +44 1273 877 873
 Email: T.Nowotny@sussex.ac.uk, Web page: http://www.sussex.ac.uk/informatics/profile206151.html
-Coinvestigators: Research fellows (PostDocs) to be named.
 == Scientific Abstract ==

@@ Line 1: / Line 1: @@
 == Scientific Abstract ==
 The aim of our project is to investigate olfactory information processing in the first stages of the olfactory pathway. We will conduct experiments and modelling studies in the pheromone subsystem of the moth Spodoptera littoralis (the cotton leafworm).
@@ Line 16: / Line 37: @@
 ** How does the pheromone system achieve its outstanding sensitivity and specificity and maintain them in the presence of noise?
 ** What is the origin and role of oscillations in the MGC or olfactory systems in general? What is the function of phase locking and synchronization and how does inhibition contribute to it?

@@ Line 13: / Line 13: @@
 * reduce the detailed models to network models of IF neurons and analyse their response and coding properties mathematically, and
 * build similar detailed and reduced models of the full MGC to analyse the following open questions (in both the oneglomerulus and full MGC models):
-- Is the connectivity of olfactory systems well described by a random network or does it follow a different construction principle?
+** Is the connectivity of olfactory systems well described by a random network or does it follow a different construction principle?
+** How does the pheromone system achieve its outstanding sensitivity and specificity and maintain them in the presence of noise?
-- How does the pheromone system achieve its outstanding sensitivity and specificity and maintain them in the presence of noise?
+** What is the origin and role of oscillations in the MGC or olfactory systems in general? What is the function of phase locking and synchronization and how does inhibition contribute to it?